Leukemia (2024)

Leukemia is a type of cancer found in your blood and bone marrow and is caused by the rapid production of abnormal white blood cells. These abnormal white blood cells are not able to fight infection and impair the ability of the bone marrow to produce red blood cells and platelets.

Leukemia can be either acute or chronic. Chronic leukemia progresses more slowly than acute leukemia, which requires immediate treatment. Leukemia is also classified as lymphocytic or myelogenous. Lymphocytic leukemia refers to abnormal cell growth in the marrow cells that become lymphocytes, a type of white blood cell that plays a role in the immune system. In myelogenous leukemia, abnormal cell growth occurs in the marrow cells that mature into red blood cells, white blood cells, and platelets. There are four broad classifications of leukemia:

  • Acute lymphocytic leukemia (ALL)
  • Acute myelogenous leukemia (AML)
  • Chronic lymphocytic leukemia (CLL)
  • Chronic myelogenous leukemia (CML)

Leukemia occurs in both adults and children. ALL is the most common form ofchildhoodleukemia, and AML is the second most common. Decades of research have led tovastly improved outcomesfor children diagnosed with ALL. The two most commonadultleukemias are AML and CLL.

Am I at Risk?

Although experts are uncertain about the causes of leukemia, they have identified several risk factors that include the following:

  • Exposure to high levels of radiation
  • Repeated exposure to certain chemicals (for example, benzene)
  • Chemotherapy
  • Down Syndrome
  • A strong family history of leukemia

Symptoms vary depending on the type and stage of leukemia, but they can include the following:

  • Fever, chills, night sweats and other flu-like symptoms
  • Weakness and fatigue
  • Swollen or bleeding gums
  • Headaches
  • Enlarged liver and spleen
  • Swollen tonsils
  • Bone pain
  • Paleness
  • Pinhead-size red spots on the skin
  • Weight loss

How Is Leukemia Treated?

Your doctor will conduct a complete blood count (CBC) to determine if you have leukemia. This test may reveal if you have leukemic cells. Abnormal levels of white blood cells and abnormally low red blood cell or platelet counts can also indicate leukemia. If you test positive for leukemia, your doctor will perform a biopsy of your bone marrow to determine which type you have.

Treatment depends on your age, general health, and type of leukemia. You might receive a combination of treatments that could include chemotherapy, biological therapy, radiation therapy, andstem cell transplantation. Patients with acute leukemia often undergo chemotherapy because this type of treatment targets fast-dividing cells. Many acute leukemia patients have responded successfully to treatment. On the other hand, because the cells divide more slowly in chronic leukemia, it is better treated withtargeted therapiesthat attack slowly dividing cells as opposed to traditional chemotherapy that targets rapidly dividing cells.

For some patients, participating in aclinical trialprovides access to experimental therapies. If you are diagnosed with leukemia, talk with your doctor about whether joining a clinical trial is right for you.

Is Leukemia Preventable?

Because the cause of leukemia remains unknown, there is no certain way to prevent it. However, avoiding exposure to solvents, such as benzene and toluene, and unnecessary exposure to x-rays is generally good practice. If you think you may be exhibiting signs of leukemia, being aware of the risk factors and symptoms and talking with your doctor are critical to early diagnosis and treatment. It is especially important for people who have a family history of leukemia to be aware of symptoms and share their family medical history with their doctors.

Chronic Myeloid Leukemia: A Patient's Journey

Where Can I Find More Information?

If you find that you are interested in learning more about blood diseases and disorders, here are a few other resources that may be of some help:

Results of Clinical Studies Published inBlood

SearchBlood, the official journal of ASH, for the results of the latest blood research. While recent articles generally require a subscriber login, patients interested in viewing an access-controlled article inBloodmay obtain a copy by e-mailing a request to theBloodPublishing Office.

Patient Groups

A list of Web links to patient groups and other organizations that provide information.

Leukemia (2024)

FAQs

Leukemia? ›

Leukemia is a broad term for cancers of the blood cells. The type of leukemia depends on the type of blood cell that becomes cancer and whether it grows quickly or slowly. Leukemia occurs most often in adults older than 55, but it is also the most common cancer in children younger than 15.

How long does a person live with leukemia? ›

Survival rate by age

The latest figures show that the 5-year survival rate for all subtypes of leukemia is 65.7% . A 5-year survival rate looks at how many people are still alive 5 years after their diagnosis. Leukemia is most common in older adults, with incidence rates rising sharply from around 55 years.

What is the early stage of leukemia? ›

Early symptoms of leukemia often include easy bleeding, frequent infections, and fatigue. In the late stages, you might develop symptoms such as confusion, slow breathing, and hallucinations. The American Cancer Society estimates that 59,610 people in the United States will receive new leukemia diagnoses in 2023.

Is leukemia a life threatening? ›

The leukemia cells divide rapidly and the disease progresses quickly. If you have acute leukemia, you'll feel sick within weeks of the leukemia cells forming. Acute leukemia is life-threatening and requires immediate initiation of therapy.

How long can leukemia go undiagnosed? ›

Chronic leukemia involves more-mature blood cells. These blood cells replicate or accumulate more slowly and can function normally for a period of time. Some forms of chronic leukemia initially produce no early symptoms and can go unnoticed or undiagnosed for years.

How bad is Stage 4 leukemia? ›

Stage IV. This is the most serious stage. The key is that your platelet count is low, which means your blood won't clot well (thrombocytopenia).

Which type of leukemia is most fatal? ›

Acute myeloid leukemia (AML) is the most fatal type of leukemia. The five-year survival rate (how many people will be alive five years after diagnosis) for AML is 29.5%. Leukemia is a cancer that usually affects white blood cells, though it can start in other types of blood cells.

What are red flags of leukemia? ›

Leukemia can produce a variety of symptoms, although most are not often apparent in the earliest stages of the malignancy. The most common symptoms of leukemia—fatigue, pale skin, weight loss and night sweats—are often attributed to other less serious conditions, such as the flu.

What are the 3 main symptoms of leukemia? ›

The main symptoms include:
  • tiredness and/or anaemia (pale complexion, weakness and breathlessness)
  • repeated infections (mouth sores, sore throat, fevers, sweats, coughing, frequent passing of urine with irritation, infected cuts and scratches, and boils)
  • increased bruising and bleeding.

What age is leukemia most common? ›

The median age of a patient diagnosed with acute myeloid leukemia (AML), chronic lymphocytic leukemia (CLL) or chronic myeloid leukemia (CML) is 65 years and older. However, most cases of acute lymphocytic leukemia (ALL) occur in people under 20 years old. The median age of an ALL patient at diagnosis is 15.

Can you live 20 years with leukemia? ›

Most people live for about 10 years, but this varies depending on how CLL behaves. People in stages 0 to II may live for 5 to 20 years without treatment. CLL has a very high incidence rate in people older than 60 years. CLL affects men more than women.

What type of leukemia is not curable? ›

It usually develops very slowly and does not always need to be treated straight away. Chronic lymphocytic leukaemia cannot usually be cured, but it can be managed with treatment.

Can you live a normal life with leukemia? ›

Advances in the treatment of blood cancers have increased the number of people living with their disease. Survival brings its own challenges and opportunities. Many experience times where their disease is under control, and they are free to 'get on' with their lives.

What is often mistaken for leukemia? ›

While leukemia is a well-known form of blood cancer, an aggressive and rare form of blood cancer, plastic plasmacytoid dendritic neoplasm (BPDCN), is often mistaken for leukemia.

What illness mimics leukemia? ›

Leukemia is commonly misdiagnosed as the following conditions:
  • Influenza.
  • Fever.
  • Pathological fracture.
  • Bleeding disorders.
  • Immune thrombocytopenic purpura.
  • Trypanosomiasis.
  • Autoimmune lymphoproliferative syndrome.

What does leukemia spots look like? ›

Petechiae, or what many people know as “leukemia spots,” are reddish, pinpoint-sized dots that can develop underneath the skin of someone who has leukemia—a cancer that occurs in blood-forming structures such as the bone marrow and lymphatic system.

What are the 5 stages of leukemia? ›

Acute Myeloid Leukemia (AML) Stages
  • M0: Undifferentiated acute myeloblastic leukemia.
  • M1: Acute myeloblastic leukemia with minimal maturation.
  • M2: Acute myeloblastic leukemia with maturation.
  • M3: Acute promyelocytic leukemia (APL)
  • M4: Acute myelomonocytic leukemia.
  • M4 eos: Acute myelomonocytic leukemia with eosinophilia.

What are the final stages of leukemia before death? ›

As you approach the end of your life, your body becomes less able to absorb food and turn it into energy. Also, the leukaemia cells will be burning up your energy supplies. As you get weaker, you may become less interested in food and drink. You may not want to eat or drink especially if swallowing becomes painful.

How fast does leukemia progress? ›

Leukaemias are grouped in two ways: the type of white blood cell affected - lymphoid or myeloid; and how quickly the disease develops and gets worse. Acute leukaemia appears suddenly and grows quickly while chronic leukaemia appears gradually and develops slowly over months to years.

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